Bisquick Impossible Pizza Pie

Featured in Satisfying Hearty Mains.

Ground beef and onions browned with Italian seasonings, combined with pepperoni and marinara, layered with cheese in a pie pan, topped with Bisquick batter and more pepperoni, baked until golden.
emliy for recipes by clare
Updated on Thu, 19 Feb 2026 14:42:12 GMT
Bisquick Impossible Pizza Pie Pin it
Bisquick Impossible Pizza Pie | recipesbyclare.com

This Bisquick pizza pie delivers all the beloved flavors of loaded pizza in a brilliant casserole format, layering seasoned ground beef, chopped pepperoni, tangy marinara sauce, and gooey mozzarella cheese under a magical Bisquick topping that transforms into a golden, fluffy crust during baking. The genius of this impossible pie lies in how the simple mixture of Bisquick, eggs, and milk poured over the filling sinks through the ingredients and rises back up to create its own perfect crust without any rolling, shaping, or traditional pizza dough skills required. What makes this Bisquick pizza pie so perfect for busy families is how it combines the comfort of pizza with the ease of casserole cooking, requiring just 35 minutes from start to table with most of that time being hands-off baking. Whether you're feeding pizza-obsessed kids who never tire of the combination, looking for a weeknight dinner that feels special without elaborate preparation, or needing to bring a crowd-pleasing dish to a potluck, this impossible pie delivers familiar flavors in an impressive format that makes everyone ask how you created something so delicious with so little effort.

I discovered impossible pies through my grandmother, who made the original Bisquick impossible cheeseburger pie throughout my childhood. While I loved her cooking, I always wanted those flavors to lean more toward pizza. Years later, I experimented with her technique to create this version, adding marinara and pepperoni. Pulling that first golden, bubbling pie from the oven was a revelation—it perfectly bridged the gap between childhood nostalgia and my adult love for a loaded pizza slice.

Master Your Ingredients

  • Ground Beef: Use one pound of beef. The fat content contributes essential flavor and helps carry the pizza seasonings throughout the filling
  • Bisquick Original: This is the secret to the 'impossible' magic. It contains the perfect ratio of leavening to create a fluffy, biscuit-like crust as it bakes
  • Mozzarella Cheese: Low-moisture shredded mozzarella is best. It provides the classic pizza stretch without releasing excess water that would make the crust gummy
  • Pepperoni: Use a mix of chopped pepperoni inside the beef for flavor and whole slices on top for that iconic pizzeria look and crispy edges
  • Marinara Sauce: One cup of your favorite jarred sauce binds the meat together. Quality matters here, as it provides the primary acidic balance to the rich cheese
  • Seasoning Blend: Italian seasoning, paprika, garlic, and red pepper flakes transform basic ground beef into a robust pizza-style sausage crumble
Bisquick Impossible Pizza Pie Pin it
Bisquick Impossible Pizza Pie | recipesbyclare.com

Creating Your Impossible Pizza Pie

Preparing the Savory Filling:
Begin by browning your ground beef and diced onions in a skillet. Once the meat is no longer pink, stir in your chopped pepperoni and seasonings. This allows the pepperoni oils to infuse the beef. Carefully drain any excess grease before stirring in the marinara sauce and minced garlic. This prevents a soggy bottom and ensures the flavors remain concentrated.
The Magic Crust Batter:
In a separate bowl, whisk together the Bisquick, milk, and eggs until smooth. The consistency should be pourable, similar to pancake batter. This mixture will sink through the meat and cheese before rising to the top to form the golden crust during the baking process.
Layering and Baking:
Spoon half the meat into a greased 9-inch pie pan, top with a cup of cheese, and repeat the layers. Pour the batter evenly over the top, reaching all the way to the edges. Arrange your pepperoni slices on top. Bake at 400°F for about 25 minutes until the center is firm and the crust is a beautiful golden brown.

Through countless baking sessions, I've learned that the 'impossible' technique is a science of density. The thinner batter finds its way to the bottom and sides while the lighter leavening agents push it back to the top. It’s a culinary magic trick that never fails to impress guests once they see the perfect layers revealed in a cross-section slice.

Creative Variations

Customize your pie just like a real pizza! Add sautéed bell peppers and mushrooms for a 'Supreme' version, or swap the ground beef for Italian sausage crumbles. For a spicy kick, use pepper jack cheese and add extra crushed red pepper flakes to the batter mixture itself.

Storage and Reheating

This pie stores beautifully in the refrigerator for up to four days. For the best results, reheat slices in an air fryer or oven at 350°F. This helps the Bisquick crust regain its slight exterior crispness, whereas a microwave will leave the crust soft and more biscuit-like in texture.

Bisquick Impossible Pizza Pie Pin it
Bisquick Impossible Pizza Pie | recipesbyclare.com

This Bisquick pizza pie is more than just a shortcut; it's a testament to how clever pantry staples can create genuinely joyful meals. Whether it's a casual Tuesday or a weekend potluck, this dish brings a touch of home-cooked magic to the table with almost zero effort. It’s pizza night, redefined.

Frequently Asked Questions

→ What is an impossible pie?
Impossible pies are magical! You pour a Bisquick mixture over the filling, and as it bakes, it sinks to the bottom and forms its own crust. It's called 'impossible' because it seems like it shouldn't work, but it does!
→ Can I use a different baking mix instead of Bisquick?
Bisquick works best for impossible pies, but you could try another all-purpose baking mix. The texture might be slightly different though.
→ Can I add other pizza toppings?
Absolutely! Add cooked sausage, mushrooms, bell peppers, olives - whatever pizza toppings you like. Just make sure any vegetables are pre-cooked and drained well.
→ Do I need to use a pie pan?
A standard 9-inch pie pan works best, but you could use a similar-sized baking dish if needed. The sides help contain everything as it bakes.
→ Why do I need to drain the grease?
Draining the grease keeps the pie from being too oily. Excess grease can also prevent the Bisquick from setting properly.
→ Can I make this ahead of time?
You can prep the meat mixture ahead and store it in the fridge, but it's best to assemble and bake fresh so the Bisquick layer turns out right.

Bisquick Impossible Pizza Pie

Ground beef, pepperoni, and mozzarella layered in a pie pan with Bisquick batter that forms a crust as it bakes.

Prep Time
10 Minutes
Cook Time
25 Minutes
Total Time
35 Minutes

Category: Hearty Mains

Difficulty: Easy

Cuisine: American

Yield: 6 Servings (1 pie)

Dietary: ~

Ingredients

→ For the Meat Filling

01 1 lb ground beef
02 1 onion, diced
03 1/2 teaspoon salt
04 1/2 teaspoon black pepper
05 1 teaspoon paprika
06 1 teaspoon Italian seasoning
07 1 teaspoon onion powder
08 1/4 teaspoon crushed red pepper flakes
09 1 tablespoon minced garlic
10 1 cup marinara sauce
11 1/4 cup chopped pepperoni (plus more for topping)

→ For the Bisquick Mixture

12 1/2 cup Bisquick baking mix
13 2 eggs
14 3/4 cup milk

→ For Assembly

15 2 cups shredded mozzarella cheese
16 Cooking spray

Instructions

Step 01

Brown the ground beef with the diced onion in a skillet over medium-high heat. Add all the seasonings - salt, pepper, paprika, Italian seasoning, onion powder, and crushed red pepper flakes.

Step 02

Once the beef is browned, add the chopped pepperoni and let it cook for a few minutes. Drain off any excess grease from the pan. Add the marinara sauce and minced garlic, stir well, then take the skillet off the heat.

Step 03

In a bowl, whisk together the Bisquick, milk, and eggs until smooth.

Step 04

Spray a pie pan with cooking spray. Layer half of the ground beef mixture in the bottom, then top with 1 cup of the shredded mozzarella. Add the rest of the ground beef on top, then the remaining 1 cup of cheese.

Step 05

Pour the Bisquick mixture evenly over the top of the ground beef and cheese layers. Top with additional pepperoni slices.

Step 06

Bake at 400 degrees for 25 minutes until the top is golden brown and set.

Step 07

Let it cool for a few minutes before slicing. Enjoy this fun twist on pizza!

Notes

  1. This is called an 'impossible pie' because the Bisquick mixture magically forms a crust as it bakes!
  2. Make sure to drain the grease well so the pie isn't too oily.
  3. You can customize the toppings - add mushrooms, bell peppers, or any pizza toppings you like.
  4. Leftovers keep in the fridge for up to 3 days and reheat well.

Tools You'll Need

  • Large skillet
  • 9-inch pie pan
  • Mixing bowl
  • Whisk

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains dairy (milk, mozzarella cheese)
  • Contains eggs
  • Contains gluten (Bisquick)
  • Contains pork (pepperoni)

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 445
  • Total Fat: 28 g
  • Total Carbohydrate: 18 g
  • Protein: 30 g